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John Z. Raymond, MD; Paul R. Gross, MD

Arch Dermatol. 1969;100(4):436-440.

Abstract
Ethylenediamine tetraacetate is a widely used preservative, especially in ophthalmic solutions. It was found to be the cause of an acute allergic conjunctivitis and periorbital dermatitis. Subsequent testing revealed two additional cases of delayed hypersensitivity to this compound.

Two of the three cases cross-reacted to ethylenediamine, a structurally related compound. Recommendation for patch testing with 1% concentration in water or petrolatum is made. The increasing problem of reactions to preservatives is discussed.

Author Affiliations
Philadelphia

From the Department of Dermatology, University of Pennsylvania and The Pennsylvania Hospital, Philadelphia.

Footnotes
Accepted for publication Feb 28, 1969.

Reprint requests to 805 Spruce St, Philadelphia 19107 (Dr. Gross).

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