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Raul Fleischmajer, MD; Georgina Faludi, MD; Stefan Krol, ARIC

Arch Dermatol. 1970;101(1):21-26.

Abstract
This is a report of eight cases of scleredema associated with diabetes mellitus. There were six men and two women, with ages ranging from 41 to 80 years. The predominant clinical features were obesity, long-standing diabetes mellitus, and scleredema; there was a high incidence of heart disease. Five patients had diabetic retinopathy. Six were maturity-onset, overt diabetics while two were chemical or latent diabetics. Most patients were resistant to antidiabetic therapy. On skin biopsies the dermis was about three times thicker than normal. Histologically there was a marked, benign hyperplasia of collagen fibers involving the dermis and subcutaneous tissue. Chemical analysis of the skin revealed an increase in collagen and glycosaminoglycans, proportional to the increase in skin thickness. Analysis of the glycosaminoglycans revealed both hyaluronic acid and dermatan sulfate.

Author Affiliations
Philadelphia

From the Section of Dermatology, Endocrinology, and Metabolic Diseases, Department of Medicine, Hahnemann Medical College and Hospital, Philadelphia.

Footnotes
Accepted for publication Sept 12, 1969.

Read before the 118th Annual Convention of the American Medical Association, New York, July 15, 1969.

Reprint requests to Hahnemann Medical College and Hospital, 230 N Broad St, Philadelphia 19102 (Dr. Fleischmajer).

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