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Studies in Pathogenesis: Triglyceride Hydrolysis by Corynebacterium acnes in Vitro

Robert E. Kellum, MD; Kathe Strangfeld; Leon F. Ray, MD

Arch Dermatol. 1970;101(1):41-47.

Abstract
Sixty-three strains of Corynebacterium acnes (C acnes) were incubated individually in vitro with three representative triglycerides. Consistent differences were found in their ability to hydrolyze these triglycerides. Seventy-five percent of strains of C acnes isolated from patients with acne vulgaris split C₁₂ triglyceride (trilaurin), 56% hydrolyzed C₁₆ triglyceride (tripalmitin), and 88% cleaved C_18:1 triglyceride (triolein). In comparison, 42% of isolates of C acnes from patients without acne vulgaris hydrolyzed C₁₂ triglyceride (trilaurin), 17% of C acnes strains split C₁₆ triglyceride (tripalmitin), and 58% split C_18:1 triglyceride (triolein). The differences were significant to the 2% confidence level.

The results suggest that distinctive strains of C acnes inhabit the sebaceous follicles of the Tetracycline hydrochloride (10µg/ml and 30µg/ ml) blocked the in vitro hydrolyzing activity of six strains of C acnes known to possess such splitting abilities.

Author Affiliations
Portland, Ore

From the Department of Dermatology, University of Oregon Medical School, Portland, Ore. Dr. Kellum is currently with the Mason Clinic, Seattle.

Footnotes
Accepted for publication Aug 11, 1969.

Reprint requests to the Mason Clinic, 1118 Ninth Ave, Seattle 98101 (Dr. Kellum).

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