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A Method for Measuring Penetration of Agents Into Human Skin

Richard B. Stoughton, MD

Arch Dermatol. 1970;101(2):160-166.

Abstract
A bioassay method for determining penetration of antimicrobial agents through the epidermis into the corium is presented.

Penicillin, erythromycin, thiabendazole, tolnaftate, and others show definite evidence of penetration by this method of measurement.

Vehicles vary in their ability to effect transport of antimicrobial agents through the epidermis. Dimethylacetamide appears to be the most effective of those studied.

Author Affiliations
La Jolla, Calif

From the Division of Dermatology, Scripps Clinic and Research Foundation, La Jolla, Calif.

Footnotes
Accepted for publication Sept 23, 1969.

Read before the 89th annual meeting of the American Dermatological Association, Scottsdale, Ariz, April 22, 1969.

Reprint requests to Scripps Clinic and Research Foundation, 476 Prospect St, La Jolla, Calif 92037.

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