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Associated With Oral Contraceptives and Mestranol

Herbert Savel, MD; James F. Madison, MD; C. Irving Meeker, MD

Arch Dermatol. 1970;101(2):187-190.

Abstract
Two patients who developed cutaneous reactions while taking contraceptive hormones are described. In both of these patients the addition of mestranol to in vitro cultures of their peripheral blood lymphocytes resulted in stimulation of lymphoblast formation as measured by the uptake of tritiated thymidine. The eruptions in these cases may represent instances of hypersensitivity to estrogenic components of contraceptive pills.

Author Affiliations
Burlington, Vt

From the departments of medicine and obstetrics and gynecology, University of Vermont College of Medicine, Burlington, Vt.

Footnotes
Accepted for publication Oct 14, 1969.

Reprint requests to Department of Medicine, University of Vermont College of Medicine, Burlington, Vt 05401 (Dr. Savel).

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