Epidermal LysosomesElectron Microscopic-Cytochemical Studies
Klaus Wolff, MD;
Elisabeth Schreiner, MD
Arch Dermatol. 1970;101(3):276-286.
Abstract
The evolution and dynamics of lysosomes in keratinocytes conform to the general lysosome concept of DeDuve and Wattiaux. Increased lysosome formation can be induced experimentally. Protein uptake by keratinocytes stimulates the synthesis of lysosomal enzymes and heterophagosomes (containing the ingested protein) are transformed into heterolysosomes which then perform digestive functions. The Golgi apparatus represents a source of primary lysosomes which supply acid phosphatase to the phagosome population.
On the other hand, injury to the epidermis enhances the formation of autolysosomes within keratinocytes. Damaged cytoplasmic components are* segregated into acid phosphatase containing vacuoles where they become subject to autodigestion.
Author Affiliations
Vienna
From the First Department of Dermatology, University of Vienna, School of Medicine, Vienna.
Footnotes
Accepted for publication Oct 11, 1969.
Reprint requests to 1. Univ-Hautklinik, Alserstrasse 4, A-1090, Vienna (Dr. Wolff).
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