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Location of Proliferating Cells in Human Epidermis
Neal S. Penneys, MD;
James E. Fulton, Jr., MD;
Gerald D. Weinstein, MD;
Phillip Frost, MD
Arch Dermatol. 1970;101(3):323-327.
Abstract
The location of the proliferative pool of cells in normal epidermis, ichthyosis vulgaris, lamellar ichthyosis, X-linked ichthyosis, epidermolytic hyperkeratosis, and psoriasis was examined using autoradiographic and projection techniques.
A significant number of thymidine-labeled cells (deoxyribonucleic acid-synthesizing cells) were found above the basal cell layer in all conditions examined. Cell proliferation in the epidermis is not limited to the basal layer but also occurs in more superficial cells.
Author Affiliations
Miami, Fla
From the Department of Dermatology, University of Miami School of Medicine, Miami, Fla.
Footnotes
Accepted for publication Oct 20, 1969.
Read before the National Meeting of the American Federation for Clinical Research, Atlantic City, NJ, May 4, 1969.
Reprint requests to Department of Dermatology, University of Miami School of Medicine, Box 875, Miami, Fla 33125 (Dr. Penneys).
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