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LCDR C. Robert Charles, MC; LCDR Edward S. Carmick, MC

Arch Dermatol. 1970;101(3):331-336.

Abstract
Six of seven patients with Raynaud's disease were subjectively benefited by the administration of "fine-particle" griseofulvin in dosages of 500 or 1,000 mg daily. Objective improvement was determined by measuring the digital temperature response following a one-minute exposure of the digit to stirred ice water maintained at 0 C. The temperature curves following griseofulvin therapy showed a much more rapid recovery toward normal when compared to the original baseline curves, and, in most instances, approached the mean control curve of 14 normal subjects.

Author Affiliations
USN; USN, Philadelphia

From the Department of Dermatology, Philadelphia Naval Hospital.

Footnotes
Accepted for publication Sept 16, 1969.

The opinions expressed herein are those of the authors and do not necessarily reflect the views of the Navy Department or the naval service at large.

Reprint requests to Department of Dermatology, Philadelphia Naval Hospital, Philadelphia 19145 (LCDR Charles).

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