 |
|
Urticaria Pigmentosa and Factitious UrticariaDirect Evidence for Release of Histamine and Other Smooth Muscle-contracting Agents in Dermographic Skin
Malcolm W. Greaves, MD, PhD, MRCP;
Jorgen Søndergaard, MD
Arch Dermatol. 1970;101(4):418-425.
Abstract
A method of continuous in vivo subcutaneous perfusion using Tyrode solution which permits direct analysis of pharmacological agents released in inflamed human skin is described. An examination was carried out using bioassay with three isolated organ preparations and spectrofluorometry. In dermographic skin of patients with urticaria pigmentosa the perfusate was consistently found to contain histamine. Additionally, smooth muscle-contracting activity against the rat uterus was detected but this was shown not to be due to bradykinin, histamine, serotonin, or acetylcholine. In urticaria factitia histamine was regularly recovered from the perfusate; bradykinin was detected in perfusates from only two of eight subjects studied. Similar experiments carried out in a group of control subjects revealed evidence of low concentrations of kinins in a minority of subjects but no other pharmacological activity was found.
Author Affiliations
Newcastle upon Tyne, England
From the University Department of Dermatology, Newcastle upon Tyne 1, England.
Footnotes
Accepted for publication June 3, 1969.
Reprint requests to University Department of Dermatology, Newcastle upon Tyne 1, England (Dr. Greaves).
 CiteULike  Connotea  Del.icio.us  Digg  Reddit  Technorati  Twitter
What's this?
THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES
The Pathogenesis of Chronic Idiopathic Urticaria
Sabroe and Greaves
Arch Dermatol 1997;133:1003-1008.
ABSTRACT
Pathogenesis of Erythromelalgia
Jorgensen and Sondergaard
Arch Dermatol 1978;114:112-114.
ABSTRACT
Urticaria: An Updated Review
Monroe and Jones
Arch Dermatol 1977;113:80-90.
ABSTRACT
Recovery of Prostaglandins in Human Primary Irritant Dermatitis
Sondergaard et al.
Arch Dermatol 1974;110:556-558.
ABSTRACT
|
