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Ralph Wier Grover, MD

Arch Dermatol. 1970;101(4):426-434.

Abstract
Six patients with an apparently unique, self-limited, primary acantholytic skin disease are described.

The elementary lesions were pruritic, discrete, edematous papules or vesiculopapules which tended to appear first on the trunk, possibly as a Koebnerlike response to nonspecific irritation, such as ultraviolet light. The two youngest patients, aged 46 and 48, developed only localized manifestations which disappeared in a few weeks. The older patients, ranging from 56 to 74 years old, had disseminated eruptions which lasted several months. Although there was a strong histologic resemblance to Darier's disease in three cases, and to Hailey-Hailey's disease in the other three, clinical considerations seem to rule out both of these diagnoses.

It is stressed that cytologic examination is most useful in recognizing the disease.

Author Affiliations
Floral Park, NY

Footnotes
Accepted for publication Aug 15, 1969.

Reprint requests to 73 Remsen Lane, Floral Park, [ill]Y 11001.

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