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Gerd Plewig, MD; John W. Petrozzi, MD; Ulrich Berendes, MD

Arch Dermatol. 1970;101(4):435-438.

Abstract
To evaluate the effectiveness of doxycycline (Vibramycin) in acne vulgaris, 62 patients with predominantly inflammatory acne were treated in a double-blind crossover study. The drug was given orally, 100 mg/day, as a single dose every morning for four weeks. No concomitant internal or external therapy was permitted. Noninflamed open and closed comedones were not affected by active or placebo treatment. A good or excellent response in the reduction of inflammatory lesions was obtained in 21 (33%) of the subjects receiving doxycycline, compared to 14 (22%) while receiving placebo. Statistically, the improvement produced by doxycycline was significant, while there was no significant improvement from the placebo.

Author Affiliations
Philadelphia

From the Department of Dermatology, University of Pennsylvania School of Medicine, Philadelphia.

Footnotes
Accepted for publication Oct 20, 1969.

Reprint requests to the Department of Dermatology, Hospital of the University of Pennsylvania, Duhring Laboratories Building, 3600 Spruce St, Philadelphia 19104 (Dr. Plewig).

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