This Article  • References  • Full text PDF  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Citing articles on HighWire  • Citing articles on Web of Science (35)  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Social Bookmarking   What's this?

Harry M. Robinson, Jr., MD; John H. Stone, MD

Arch Dermatol. 1970;101(4):462-465.

Abstract
Adverse cutaneous reactions of varying degrees of intensity occur frequently after institution of diphenylhydantoin (Dilantin) therapy. During the past year eight patients developed a diphenylhydantoin-induced syndrome 14 days after therapy was initiated. The picture presented simulated a severe infectious exanthem and was characterized by a generalized erythematous macular eruption, massive edema of the face, erythema and edema of the oropharynx, fever, and generalized lymphadenopathy. Involution of the eruption was characterized by exfoliation similar to that observed in scarlet fever. The laboratory findings, similar in all patients, revealed marked elevation in the total eosinophil count, elevation of urea nitrogen, serum transaminase, and lactic dehydrogenase with reversal of albumin-globulin ratio. There was prompt response to treatment with systemic steroids.

Author Affiliations
Baltimore

From the Division of Dermatology, Department of Medicine, University of Maryland School of Medicine, Baltimore 21201.

Footnotes
Accepted for publication Nov 19, 1969.

Read before the section on dermatology during the 118th annual convention of the American Medical Association, New York, July 15, 1969.

Reprint requests to Division of Dermatology, University of Maryland School of Medicine, Baltimore 21201 (Dr. Robins[ill]n).

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

Anticonvulsant Hypersensitivity Syndrome
Vittorio and Muglia
Arch Intern Med 1995;155:2285-2290.
ABSTRACT  

Drug Rash in a Hemiplegic
Basak et al.
Arch Dermatol 1990;126:688-689.
ABSTRACT  

Dermatologic Problems in the Intensive Care Unit: Part IV
Berman and Silvestri
J Intensive Care Med 1986;1:224-239.
ABSTRACT  

Phenytoin Hypersensitivity Reaction
Stanley and Fallon-Pellicci
Arch Dermatol 1978;114:1350-1353.
ABSTRACT  

Phenytoin-Induced Pseudolymphoma Syndrome: An Immunologic Study
Charlesworth
Arch Dermatol 1977;113:477-480.
ABSTRACT  

Rates of Cutaneous Reactions to Drugs: A Report From the Boston Collaborative Drug Surveillance Program
Arndt and Jick
JAMA 1976;235:918-923.
ABSTRACT  

DIPHENYLHYDANTOIN THERAPY
Arch Dermatol 1970;102:561-561.
ABSTRACT