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Epidermolytic Hyperkeratosis—Treatment With Methotrexate

James R. Groundwater, MD; Howard I. Maibach, MD

Arch Dermatol. 1970;101(5):528-530.

Abstract
In contrast to recently reported successful methotrexate therapy of congenital bullous ichthyosiform erythroderma (CBIE), two cases failed to respond to the dosages of methotrexate normally used in psoriasis. Thiamiprine was also without effect. This was despite the demonstration of markedly increased epidermal turnover in these patients using tritiated thymidine autoradiography. We suspect the failure to respond is because the increased epidermal cell turnover in this disease is a secondary phenomenon involving mechanisms not responsive to antimetabolites.

Author Affiliations
San Francisco

From the Division of Dermatology, Department of Medicine, University of California School of Medicine, San Francisco.

Footnotes
Accepted for publication Dec 3, 1969.

Reprint requests to Division of Dermatology, 1096-HSE, University of California, San Francisco Medical Center, San Francisco 94122 (Dr. Maibach).

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