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Modification of the Stoughton-McKenzie Assay

Virgil A. Place, MD, FACP; Juan Giner Velazquez, MD; Kenneth H. Burdick, MD

Arch Dermatol. 1970;101(5):531-537.

Abstract
Strict control of experimental variables yields a vasoconstrictor assay of extreme sensitivity and high precision that can be used to develop important information relating chemical structure and vasoconstriction following topical application to normal skin. In this assay fluocinolide has about five times the potency of the standard fluocinolone acetonide while triamcinolone acetonide and betamethasone valerate have approximately the same activity as fluocinolone acetonide. Hydrocortisone with only one thousandth the activity of fluocinolone acetonide is at the lower limit of sensitivity of the assay.

Author Affiliations
Palo Alto, Calif; Mexico City; Palo Alto, Calif

From the Institute of Clinical Medicine, Syntex Research, Mexico City (Dr. Velazquez), the Institute of Clinical Medicine, Syntex Research (Dr. Burdick), and ALZA Research (Dr. Place), Palo Alto, Calif.

Footnotes
Accepted for publication Sept 24, 1969.

Reprint requests to Institute of Clinical Medicine, Syntex Research, 3401 Hillview Ave, Standford Industrial Park, Palo Alto, Calif 94304 (Dr. Burdick).

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