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Albert M. Kligman, PhD; Victor R. Wheatley, PhD, DSc; Otto H. Mills, MA

Arch Dermatol. 1970;102(3):267-275.

Abstract
The components in human sebum that mediate the formation of comedones in the rabbit ear were evaluated by applying various sebum fractions as well as individual authentic components of sebum. Practically all the major constituents of sebum had some activity. The activities of the triglycerides and waxes were respectively moderate and weak. Among the saturated fatty acids activity began at C₁₀, reached a peak at C₁₂ and C₁₄, lessened at C₁₆ and C₁₈, and was absent at C₂₀. Monounsaturation increased comedogenicity but high unsaturation had the opposite effect. Irritancy and comedogenicity were shown to be unrelated properties. The lower fatty acids C₃ and C₅ were highly irritating and noncomedogenic while C₁₆ and C₁₈ were comedogenic and non-irritating. The sebum of various animals had borderline comedogenicity because of the absence of triglycerides and fatty acids.

Author Affiliations
Philadelphia; New York; Philadelphia

From the Department of Dermatology, University of Pennsylvania School of Medicine, Philadelphia (Dr. Kligman and Mr. Mills), and the New York University School of Medicine, New York (Dr. Wheatley).

Footnotes
Accepted for publication April 14, 1970.

Reprint requests to Department of Dermatology, Hospital of the University of Pennsylvania, Duhring Laboratories Bldg, 3600 Spruce St, Philadelphia 19104 (Dr. Kligman).

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