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Development of Epidermal Neoplasms

Harry L. Wechsler, MD; Francis J. Krugh, MD; Anthony N. Domonkos, MD; S. Randolph Scheen, MD; Chester L. Davidson, Jr., MD

Arch Dermatol. 1970;102(4):374-380.

Abstract
The emergence of epidermal epitheliomas in the scars of patients with polydysplastic epidermolysis bullosa is the result of a carcinogenic process similar to that observed in the scars of thermal burns and other chronic cicatrices. In three of the four cases, the patients developed multiple, well-differentiated squamous-cell cancers; in one patient basal-cell epitheliomas were also present. Confirmation of cancer histologically was difficult because of limitations in distinguishing pseudoepitheliomatous hyperplasia from squamous-cell cancer. There was no doubt of carcinomatous conversion biologically, however, as metastases occurred in the patients. Therapy was inadequate; and despite its limitations, surgery seems to be the treatment of choice.

Author Affiliations
Pittsburgh; New York; Louisville, Ky

From the departments of dermatology, Western Pennsylvania College, Pittsburgh (Dr. Wechsler), Homestead (Pa) Hospital (Dr. Krugh), the University of Louisville (Ky) School of Medicine (Drs. Scheen and Davidson), and the Presbyterian Hospital and College of Physicians and Surgeons, Columbia University, New York (Dr. Domonkos).

Footnotes
Accepted for publication July 9, 1970.

Reprint requests to 502 Fifth Ave, McKeesport, Pa 15132 (Dr. Wechsler).

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