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Lawrence M. Solomon, MD; David Fretzin, MD; Samuel Pruzansky, DDS

Arch Dermatol. 1970;102(4):381-385.

Abstract
The clinical findings in nine patients with Apert's syndrome (acrocephalosyndactyly) revealed seven postpuberal patients to have widespread moderate-to-severe acne vulgaris on the face, chest, back, and in an unusual manner, the forearms. Since forearm acne is rare, the frequency of this finding without additional evidence of virilization in a group of patients with Apert's syndrome suggested they may have an abnormality of end-organ androgen disposition.

Author Affiliations
Chicago

From the Department of Dermatology, College of Medicine (Drs. Solomon and Fretzin), and the Center for Craniofacial Anomalies (Drs. Solomon and Pruzansky), University of Illinois Medical Center, Chicago.

Footnotes
Accepted for publication May 15, 1970.

Reprint requests to Department of Dermatology, College of Medicine, University of Illinois Medical Center, PO Box 6998, Chicago 60680 (Dr. Solomon).

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