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E. Dorinda Loeffel, MD; John S. Meyer, MD

Arch Dermatol. 1970;102(4):451-456.

Abstract
A vaccinia virus infection that initially mimicked pyoderma proved life-threatening to a patient with Darier's disease (keratosis follicularis). Recognition of intracytoplasmic inclusions in touch preparations made from biopsied skin supported the suspected diagnosis of vaccinia virus infection and led to treatment with vaccinia immune globulin. The diagnosis of eczema vaccinatum was proved first through visualization of the virus by electron microscopy and later by rising antibody titers.

Author Affiliations
Stanford, Calif; St. Louis

From the departments of dermatology and pathology, University of Missouri Medical Center, Columbia.

Footnotes
Accepted for publication July 14, 1970.

Reprint requests to Department of Pathology and Laboratory Medicine, the Jewish Hospital of St. Louis, 216 S Kingshighway, St. Louis 63110 (Dr. Meyer).

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