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Ervin Epstein, Jr., MD; Arthur R. Ugel, MD

Arch Dermatol. 1970;102(5):504-506.

Abstract
Topical applications of aqueous solutions of mechlorethamine hydrochloride were given to 12 patients with resistant psoriasis. Ten had definite improvement of their lesions, some with dramatic resolution. No systemic toxicity was detected in any patient but the development of hypersensitivity to this drug precluded its prolonged use.

Author Affiliations
Bethesda, Md

From the Dermatology Branch, National Cancer Institute, National Institutes of Health, Bethesda. Md.

Footnotes
Accepted for publication July 29, 1970.

Reprint requests to Room 12N238, Bldg 10, National Institutes of Health, Bethesda, Md 20014 (Dr. Ugel).

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