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Robert G. Freeman, MD

Arch Dermatol. 1970;102(5):521-526.

Abstract
By exposing Hep-2 cells in tissue culture and erythrocytes to chemicals in nontoxic concentrations and then to long ultraviolet and visible light, a photosensitizing cytotoxicity was demonstrated with 17 different compounds representing ten different classes of chemicals. Some compounds demonstrated a prompt and irreversible interaction with the cells while others required a delay of 60 to 90 minutes for the interaction to occur. The bond between cell and drug tended to become more firm with longer incubation until it was irreversible by washing of the cells. No effect on acid phosphatase or succinic dehydrogenase staining was detected.

Author Affiliations
Dallas

From the departments of dermatology and pathology, Baylor College of Medicine, Houston.

Footnotes
Accepted for publication July 31, 1970.

Read before the annual session of the American Dermatological Association, Boca Raton, Fla, March 20, 1970.

Reprint requests to Department of Pathology, University of Texas Southwestern Medical School, 5323 Harry Hines Blvd, Dallas 75235 (Dr. Freeman).

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