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A Case Report

Eugene Mirrer, MD; Joseph McGuire, MD

Arch Dermatol. 1970;102(5):548-551.

Abstract
We wish to describe the therapy given to a 12-year-old boy with lamellar ichthyosis. His disease had been refractory to many forms of topical and systemic treatment until the initiation of treatment with tretinoin (all-trans-retinoic acid, vitamin A acid), in alcohol which was applied topically. Irritation produced by tretinoin was overcome by decreasing the frequency of application. Although the mode of action is not understood, the beneficial effect of tretinoin for lamellar ichthyosis appears to be established.

Author Affiliations
New Haven, Conn

From the Section of Dermatology, Yale-New Haven Medical Center, New Haven, Conn.

Footnotes
Accepted for publication July 21, 1970.

Reprint requests to Yale-New Haven Medical Center, 333 Cedar St, New Haven, Conn 06510 (Dr. McGuire).

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