This Article  • References  • Full text PDF  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Citing articles on HighWire  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Social Bookmarking   What's this?

III. Employing Clinically Normal Skin

Thomas K. Burnham, MB, BS; Gerald Fine, MD

Arch Dermatol. 1971;103(1):24-32.

Abstract
Clinically normal skin biopsies from 220 patients were tested by the direct fluorescent antibody technique for the "band" of localized immunoglobulins found at the dermal-epidermal junction in lupus erythematosus (LE) skin. Diseases studied included systemic lupus erythematosus (SLE), discoid lupus erythematosus (DLE), rheumatoid arthritis, scleroderma, and various miscellaneous dermatoses including bullous diseases. Only SLE and bullous pemphigoid demonstrated the band. The SLE band differed morphologically from that of bullous pemphigoid. The band-positive SLE patients had severer disease and a higher incidence of certain laboratory abnormalities associated with more severe SLE than the band negatives. Kidney involvement occurred three times, fever 3 1/2 times, and marked weight loss two times as frequently in the band positive patients. The presence of the band in clinically normal skin is, therefore, both diagnostic and probably prognostic, confirming a clinical diagnosis of SLE even in patients without LE skin lesions, and simultaneously suggesting a poorer prognosis.

Author Affiliations
London; Detroit

From the departments of dermatology (Dr. Burnham) and pathology (Dr. Fine), Henry Ford Hospital, Detroit.

Footnotes
Accepted for publication Aug 18, 1970.

Read before the Section of Dermatology at the 119th annual convention of the American Medical Association, Chicago, June 22, 1970.

Reprint requests to Department of Dermatology, Henry Ford Hospital, Detroit 48202 (Dr. Burnham).

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

The composition of the lupus band test (LBT) on the sun-protected non-lesional (SPNL) skin in patients with cutaneous lupus erythematosus (CLE)
Cardinali et al.
Lupus 1999;8:755-760.
ABSTRACT  

Pathology, immunopathology, and immunohistochemistry in cutaneous lupus erythematosus
David-Bajar and Davis
Lupus 1997;6:145-157.
 

Twenty Percent of Biopsy Specimens From Sun-Exposed Skin of Normal Young Adults Demonstrate Positive Immunofluorescence
Fabre et al.
Arch Dermatol 1991;127:1006-1011.
ABSTRACT  

Usefulness of Direct Immunofluorescence in Patients With Lupus Erythematosus
Dahl
Arch Dermatol 1983;119:1010-1017.
ABSTRACT  

Variability of the Lupus Band Test: Results in 18 Patients With Systemic Lupus Erythematosus
Jacobs et al.
Arch Dermatol 1983;119:883-889.
ABSTRACT  

The Lupus Band Test as a Measure of Disease Activity in Systemic Lupus Erythematosus
Halberg et al.
Arch Dermatol 1982;118:572-576.
ABSTRACT  

Case for Diagnosis: Vesicular Pemphigoid? Immunofluorescence Microscopy Studies
Burnham and Nims
Arch Dermatol 1982;118:506-511.
ABSTRACT  

Skin Immunopathology in Systemic Lupus Erythematosus
Brown and Yount
JAMA 1980;243:38-42.
ABSTRACT  

Circumscribed Scleroderma With Immunologic Evidence of Systemic Lupus Erythematosus: Report of a Case and Review of the Literature
Mitchell et al.
Arch Dermatol 1980;116:69-73.
ABSTRACT  

Speckled (Particulate) Epidermal Nuclear IgG Deposition in Normal Skin: Correlation of Clinical Features and Laboratory Findings in 46 Patients With a Subset of Connective Tissue Disease Characterized by Antibody to Extractable Nuclear Antigen
Prystowsky and Tuffanelli
Arch Dermatol 1978;114:705-710.
ABSTRACT  

Cicatricial Pemphigoid (Brunsting-Perry Type) Case Report and Immunofluorescence Findings
Jacoby et al.
Arch Dermatol 1978;114:779-781.
ABSTRACT  

Epidermal Nucleolar IgG Deposition in Clinically Normal Skin: Clinical and Serologic Features of Eight Patients
Prystowsky et al.
Arch Dermatol 1978;114:536-538.
ABSTRACT  

Lupus Band Test-Reply
Monroe
Arch Dermatol 1978;114:126-127.
ABSTRACT  

Lupus Band Test
Monroe
Arch Dermatol 1977;113:830-834.
ABSTRACT  

"Band" Test in Connective Tissue Disease
BURNHAM
ANN INTERN MED 1975;83:909-910.
ABSTRACT  

Discoid Lupus Erythematosus As Part of a Larger Disease Spectrum: Correlation of Clinical Features With Laboratory Findings in Lupus Erythematosus
Prystowsky and Gilliam
Arch Dermatol 1975;111:1448-1452.
ABSTRACT  

The Immunofluorescent "Band" Test in Mixed Connective Tissue Disease
LEVITIN et al.
ANN INTERN MED 1975;83:53-55.
ABSTRACT  

Lupus Erythematosus Profundus Following Thrombocytopenic Purpura
Zweiman et al.
Arch Dermatol 1975;111:347-351.
ABSTRACT  

Antinuclear Antibodies: II. The Prognostic Significance of Nuclear Immunofluorescent Patterns in Lupus Erythematosus
Burnham
Arch Dermatol 1975;111:203-207.
ABSTRACT  

Skin Immunofluorescence Studies on Lupus Erythematosus and Other Antinuclear-Antibody-Positive Diseases
GROSSMAN et al.
ANN INTERN MED 1974;80:496-500.
ABSTRACT  

Immunoglobulins in the Larynx in Systemic Lupus Erythematosus
Gilliam and Cheatum
Arch Dermatol 1973;108:696-697.
ABSTRACT  

Direct Immunofluorescence of Bullous Systemic Lupus Erythematosus
Pedro and Dahl
Arch Dermatol 1973;107:118-120.
ABSTRACT  

Immunofluorescent Skin Test in Systemic Lupus Erythematosus: Lack of Relationship With Renal Disease
Caperton et al.
JAMA 1972;222:935-937.
ABSTRACT  

Lupus Erythematosus
Tuffanelli
Arch Dermatol 1972;106:553-566.
ABSTRACT  

Indirect Cutaneous Immunofluorescence: I. Morphologic Observations in Bullous Diseases, Malignancies, and Connective Tissue Diseases
Burnham and Fine
Arch Dermatol 1972;105:52-58.
ABSTRACT