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Blood Levels of Methotrexate and the Treatment of Psoriasis
Kenneth M. Halprin, MD;
Kiyomi Fukui, MD;
Akira Ohkawara, MD
Arch Dermatol. 1971;103(3):243-249.
Abstract
Methotrexate (Amethopterin [Britain]) is completely and rapidly absorbed in the usual therapeutic dosages. In order to maintain a blood level for approximately 36 hours, small oral doses should be given every eight hours or sooner. Twenty-three of 26 patients had good responses to a regimen of four such doses in a 24-hour period of each week.
Author Affiliations
Miami, Fla
From the Dermatology Service, Veterans Administration Hospital, and the Department of Dermatology, University of Miami School of Medicine, Miami, Fla.
Footnotes
Accepted for publication Oct 21, 1970.
Read in part before the meeting of the American Dermatological Association, Boca Raton, Fla, March 20, 1970.
Reprint requests to Veterans Administration Hospital, 1201 NW 16th St, Miami, Fla 33125 (Dr. Halprin).
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