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An Enzyme Histochemical and Ultrastructural Study

Paul R. Vandersteen, MD; Sigfrid A. Muller, MD

Arch Dermatol. 1971;103(4):362-370.

Abstract
Skin biopsies done in three patients with erythrokeratodermia variabilis (EKV) seen in consecutive generations of one family were studied by enzyme histochemical and light and electron microscopic methods. Distinctive histopathologic, ultrastructural, and enzyme histochemical findings are in agreement with the thesis that erythrokeratodermia is a disease suis generis and not related to congenital ichthyosiform erythroderma. We suggest that EKV is a primary disorder of keratinization in which the basic abnormality is epidermal in origin.

Author Affiliations
Rochester, Minn

From the Department of Dermatology, Mayo Graduate School of Medicine (University of Minnesota) (Dr. Vandersteen), and Mayo Clinic and Mayo Foundation (Dr. Muller), Rochester, Minn.

Footnotes
Accepted for publication Oct 26, 1970.

Reprint requests to Section of Publications, Mayo Clinic, Rochester, Minn 55901.

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