Ultrastructure of Abnormal Cells: In Sezary Syndrome, Mycosis Fungoides, and Parapsoriasis en Plaque

doi:10.1001/archderm.1971.04000160025005

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Vol. 103 No. 4, April 1971

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Ultrastructure of Abnormal Cells

In Sezary Syndrome, Mycosis Fungoides, and Parapsoriasis en Plaque

Marvin A. Lutzner, MD; James W. Hobbs, MD; Peter Horvath, MD

Arch Dermatol. 1971;103(4):375-386.

Abstract

A cell with characteristic ultrastructural features was foundin tissues from all six Sezary patients studied. This cell hasa highly irregular, serpentine nucleus, which in three-dimensionalreconstruction appears to be cerebriform and composed of highlyfolded sheets. Abnormal cells were also found in tissues from34 of 38 patients with mycosis fungoides (MF). The nuclei ofthese MF cells were also irregular, but less so than Sezarycell nuclei. These MF cells were also found in six of eightpatients with parapsoriasis en plaque. In order to determinethe diagnostic specificity of these abnormal MF cells, skinfrom 33 control patients with a variety of malignant and benignskin diseases was studied. Cells similar to MF cells were foundin skin from three of these control patients; so, it appearsthat the presence of this unusual cell is not absolutely specificfor the diagnosis of MF.

Author Affiliations

Bethesda, Md; Washington, DC

From the Dermatology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Md (Dr. Lutzner), and the departments of dermatology, Howard University (Dr. Hobbs) and Georgetown University (Dr. Horvath), Washington, DC.

Footnotes

Accepted for publication Sept 19, 1970.

Reprint requests to Dermatology Branch, National Cancer Institute,National Institues of Health, Bldg 10, Room 12-N-238, Bethesda,Md 20014 (Dr. Lutzner).

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