 |
|
Familial Progressive Hyperpigmentation
Marvin E. Chernosky, MD;
David E. Anderson, PhD;
Jeffrey P. Chang, PhD;
Margery W. Shaw, MD;
Marvin M. Romsdahl, MD, PhD
Arch Dermatol. 1971;103(6):581-598.
Abstract
Familial progressive hyperpigmentation is a distinctive, dominantly inherited genodermatosis, characterized by patches of hyperpigmentation present at birth which increase in size and number with age. In contrast to normal areas, the epidermis of the dark skin and mucous membranes appears to show an increase in number and average size of melanin granules, and seemingly more premelanosomes. Genetic findings from one family coupled with glucose-6-phosphate dehydrogenase studies were not conclusive enough for determining whether the inheritance pattern was autosomal or sex-linked. Additional genetic studies, sex chromatin counts, chromosome analysis, determinations of circulating tyrosinase and pituitary-adrenal hormone levels, porphyrin determinations, urinary and plasma aminograms, and other laboratory and clinical investigations failed to elucidate the pathogenesis. Normal and hyperpigmented skin showed no differences in 3,4 dihydroxyphenylalanine-positive cell counts, histopathology of the dermis, temperature, response to ultraviolet light, or thermal and methacholine-chloride-induced eccrine sweating.
Author Affiliations
Houston
From the Section of Dermatology, Hermann Hospital and Baylor College of Medicine (Dr. Chernosky), and the departments of biology (Drs. Anderson and Shaw), pathology (Dr. Chang), and surgery (Dr. Romsdahl), the University of Texas M. D. Anderson Hospital and Tumor Institute at Houston, Houston.
Footnotes
Accepted for publication Nov 11, 1970.
Read before the American Dermatological Association, Boca Raton, Fla, March 23, 1970.
Reprint requests to 703 Hermann Professional Bldg, Houston 77025 (Dr. Chernosky).
 CiteULike  Connotea  Delicious  Digg  Facebook  Reddit  Technorati  Twitter
What's this?
THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES
Skin pigmentary anomalies and mosaicism for an acentric marker chromosome originating from 3q
Portnoi et al.
J. Med. Genet. 1999;36:246-250.
ABSTRACT
| FULL TEXT
Universal Inherited Melanodyschromatosis: A Case of Melanosis Universalis Hereditaria?
Rebora and Parodi
Arch Dermatol 1989;125:1442-1443.
ABSTRACT
Zebra-like Hyperpigmentation in an Infant With Multiple Congenital Defects
Alimurung et al.
Arch Dermatol 1979;115:878-881.
ABSTRACT
Universal Acquired Melanosis: The Carbon Baby
Ruiz-Maldonado et al.
Arch Dermatol 1978;114:775-778.
ABSTRACT
Progressive Cribriform and Zosteriform Hyperpigmentation
Rower et al.
Arch Dermatol 1978;114:98-99.
ABSTRACT
Hyperpigmented Tinea Versicolor
Allen et al.
Arch Dermatol 1976;112:1110-1112.
ABSTRACT
Idiopathic Pigmentation of the Upper Back
El Zawahry
Arch Dermatol 1974;109:101-102.
ABSTRACT
|
