This Article  • References  • Full text PDF  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Citing articles on HighWire  • Citing articles on Web of Science (99)  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Social Bookmarking   What's this?

An Endocytotic Organelle

Ken Hashimoto, MD

Arch Dermatol. 1971;104(2):148-160.

Abstract
Intradermally injected peroxidase was found in the Langerhans' cell granules of the epidermal Langerhans' cells. As time elapsed, the number of stained granules increased, reaching the maximum at 22 hours, and tended to concentrate near the Golgi zone. Since the peroxidase molecule does not cross the plasma membrane, this suggested (1) ingestion of peroxidase by the Langerhans' cell granules at the cell periphery and (2) migration of such granules into the cell interior. At the cell periphery various types of close apposition of the plasma membrane with gap distance ranging from 30 Angstroms (gap junction) to 350 A (Langerhans' cell type) were found. They too migrated into the cell interior. This suggested that the so-called Langerhans' cell granule is just one type of plasma membrane apposition or invagination which this cell can produce.

Author Affiliations
Memphis

From the Veterans Administration Hospital and the Division of Dermatology, University of Tennessee College of Medicine, Memphis. Dr. Hashimoto is an Awardee of Medical Investigatorship supported in part by VA part I Designated Research Funds.

Footnotes
Accepted for publication Feb 9, 1971.

Reprint requests to Veterans Administration Hospital, 1030 Jefferson Ave, Memphis 38104 (Dr. Hashimoto).

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

Disruption of the langerin/CD207 Gene Abolishes Birbeck Granules without a Marked Loss of Langerhans Cell Function
Kissenpfennig et al.
Mol. Cell. Biol. 2005;25:88-99.
ABSTRACT | FULL TEXT  

Eosinophilic Granuloma: Presence of OKT6-Positive Cells and Good Response to Intralesional Steroid
Hashimoto et al.
Arch Dermatol 1985;121:770-774.
ABSTRACT  

Epidermal Melanocytes in Eruptive Xanthomas: An Ultrastructural Study
Silvers et al.
Arch Dermatol 1973;107:847-852.
ABSTRACT  

Electron Microscopic Study of Reticulohistiocytoma: An Unusual Case of Congenital, Self-Healing Reticulohistiocytosis
Hashimoto and Pritzker
Arch Dermatol 1973;107:263-270.
ABSTRACT  

Birbeck Granules Are Subdomains of Endosomal Recycling Compartment in Human Epidermal Langerhans Cells, Which Form Where Langerin Accumulates
Mc Dermott et al.
Mol. Biol. Cell 2002;13:317-335.
ABSTRACT | FULL TEXT