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Beta Adrenergic Stimulation of Endogenous Epidermal Cyclic AMP Formation
John A. Powell, MD;
Elizabeth A. Duell, PhD;
John J. Voorhees, MD
Arch Dermatol. 1971;104(4):359-365.
Abstract
We envision the epidermal chalone mechanism as an epinephrine-activated cascade of intra-epidermal molecular events whereby the feedback control of epidermal cell division is mediated via adenosine 3',5'-monophosphate (cyclic AMP). Sutherland's first criterion of a cyclic AMP mediated event appears to have been satisfied in that isoproterenol (1 x 10-6M) produced a threefold (P < 0.001) rise in cyclic AMP level within three minutes in epidermal target tissue which was followed by inhibition of epidermal cell division. Since keratinocytes comprise approximately 95% of epidermal volume, we suggest that the majority of cyclic AMP measured was synthesized in keratinocytes.
Author Affiliations
Ann Arbor, Mich
From the Department of Dermatology, University of Michigan Medical School, Ann Arbor.
Footnotes
Accepted for publication June 15, 1971.
Read in part before the American Society for Experimental Pathology at the 55th FASEB annual meeting, Chicago, April 17, 1971.
Reprint requests to R6558 Kresge Medical Research Bldg, University of Michigan Medical School, Ann Arbor, Mich 48104 (Dr. Voorhees).
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