 |
|
Multiple Congenital Giant Nevocellular Nevi With HalosA Clinical and Electron Microscopic Study
Richard S. Berger, MD;
John J. Voorhees, MD
Arch Dermatol. 1971;104(5):515-521.
Abstract
A patient had multiple congenital giant nevocellular nevi all of which had halos but none of which regressed. This unusual phenomenon was studied histochemically and ultrastructurally in an attempt to compare this process with ordinary halo nevi and other known leukodermatous disorders. Histochemical studies demonstrated a decrease in melanin and tyrosinase activity in the area of the halo. Although the relative frequency of clear cells in the halo remained normal, electron microscopy revealed an increased density of Langerhans cells in the hypochromic zone and a variable deficit in the number of melanocytes. Ultrastructurally these melanocytes were markedly deficient in melanized melanosomes. These results suggest that either we may be dealing with an unusual form of leukoderma acquisitum centrifugum or a variant of one of the other congenital leukodermatous diseases.
Author Affiliations
Ann Arbor, Mich
From the Department of Dermatology, University of Michigan Medical School, Ann Arbor. Dr. Berger is now with the University of Missouri School of Medicine, Columbia.
Footnotes
Accepted for publication April 16, 1971.
Reprint requests to Division of Dermatology, University Hospital, Columbia, Mo 65201 (Dr. Berger).
 CiteULike  Connotea  Del.icio.us  Digg  Reddit  Technorati  Twitter
What's this?
THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES
Halo Congenital Nevus Undergoing Spontaneous Regression: Involvement of T-Cell Immunity in Involution and Presence of Circulating Anti--Nevus Cell IgM Antibodies
Tokura et al.
Arch Dermatol 1994;130:1036-1041.
ABSTRACT
Halo Congenital Nevus
Brownstein et al.
Arch Dermatol 1977;113:1572-1575.
ABSTRACT
|
