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Elizabeth A. Duell, PhD; John J. Voorhees, MD; William H. Kelsey; Emmet Hayes, MA

Arch Dermatol. 1971;104(6):601-610.

Abstract
Adenyl cyclase was found in a 17,000 g particulate fraction of gently homogenized newborn rat epidermis. Isoproterenol produced a statistically significant 40% (P <.005) stimulation of this enzyme. We have previously shown a 205% stimulation of the enzyme by isoproterenol with intact epidermis from adult rats; thus it is apparent that the broken-cell preparation of epidermal adenyl cyclase has a decreased sensitivity to the hormone, which is characteristic of many adenyl cyclases from various tissues. Sodium fluoride, a stimulator of most adenyl cyclases, produced a 139% increase in enzyme activity. Propranolol, a beta-adrenergic antagonist, prevented the stimulation of epidermal adenyl cyclase by the beta-adrenergic agonist, isoproterenol. Thus the second criterion used to characterize a hormonally induced response, in this case the betaadrenergic inhibition of epidermal cell division, mediated by adenosine 3',5'-monophosphate (cyclic AMP) appears to have been satisfied.

Author Affiliations
Ann Arbor, Mich

From the Department of Dermatology, University of Michigan Medical School, Ann Arbor.

Footnotes
Accepted for publication Sept 15, 1971.

Read in part before the American Society for Experimental Pathology at the 55th FASEB annual meeting, Chicago, April 17, 1971.

Reprint requests to R6558 Kresge Medical Research Bldg, University of Michigan Medical School, Ann Arbor, Mich 48104 (Dr. Voorhees).

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