 |
|
Dibutyryl Cyclic AMP Inhibition of Epidermal Cell Division
John J. Voorhees, MD;
Elizabeth A. Duell, PhD;
William H. Kelsey
Arch Dermatol. 1972;105(3):384-386.
Abstract
Dibutyryl adenosine 3',5'-monophosphate (cyclic AMP), but not sodium butyrate or adenosine 5'-monophosphate (5'-AMP) produced a dose-dependent epidermal mitotic inhibition. Previously we showed that isoproterenol inhibits epidermal mitosis, stimulates adenyl cyclase activity in broken epidermal cells, and stimulates cyclic AMP formation in intact epidermis. This data and results from the present study strongly suggest that cyclic AMP is one and possibly a major mediator of epidermal mitotic control. Our findings together with recent evidence that cyclic AMP inhibits cell growth rate while promoting differentiation in cultured cells suggests the following: (1) the rate of epidermal proliferation may be inversely proportional to the intraepidermal cyclic AMP level; (2) the 12-fold accelerated proliferation rate and glycogen accumulation of psoriatic epidermis might be due to low intraepidermal cyclic AMP concentrations.
Author Affiliations
Ann Arbor, Mich
From the Department of Dermatology, University of Michigan Medical School, Ann Arbor.
Footnotes
Accepted for publication Oct 5, 1971.
Read in part before the American Society for Experimental Pathology at the 55th annual meeting of the FASEB annual meeting, Chicago, April 17, 1971
Reprint requests to R6558 Kresge Medical Research Bldg, University of Michigan Medical School, Ann Arbor, Mich 48104 (Dr. Voorhees).
 CiteULike  Connotea  Del.icio.us  Digg  Reddit  Technorati  Twitter
What's this?
THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES
Newer Concepts of Atopic Dermatitis
Hanifin and Lobitz
Arch Dermatol 1977;113:663-670.
ABSTRACT
Defects and Deficiency of Adenyl Cyclase in Psoriatic Skin
Wright et al.
Arch Dermatol 1973;107:47-53.
ABSTRACT
Decreased Cyclic AMP in the Epidermis of Lesions of Psoriasis
Voorhees et al.
Arch Dermatol 1972;105:695-701.
ABSTRACT
|
