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Herschel S. Zackheim, MD; James E. Arnold, MD; Eugene M. Farber, MD; Alvin J. Cox, Jr., MD

Arch Dermatol. 1972;105(5):702-706.

Abstract
Aqueous solutions of mechlorethamine (Mustargen) hydrochloride (0.055 to 0.00625%) have been used in courses of seven to ten days on lesions of psoriasis in 42 patients. A significant involutionary effect was obtained with the 0.0125% to 0.05% concentrations, particularly on the trunk. The rate of contact sensitization ranged from 50% to more than 80%, and was highest with the 0.05% concentration. Occasional Koebner reactions and paradoxical results were noted. The high rate of sensitization precludes the use of this agent in the practical management of psoriasis.

Author Affiliations
Stanford, Calif

From the Department of Dermatology, Stanford (Calif) University School of Medicine. Dr. Zackheim is now with the University of California School of Medicine, San Francisco.

Footnotes
Accepted for publication Oct 1, 1971.

Reprint requests to the Department of Dermatology, University of California School of Medicine, San Francisco 94122 (Dr. Zackheim).

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