This Article  • References  • Full text PDF  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Citing articles on HighWire  • Citing articles on Web of Science (65)  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Social Bookmarking   What's this?

William S. Logan, MD

Arch Dermatol. 1972;105(5):748-753.

Abstract
The effect of vitamin A on epidermal dynamics is complicated by many variables, including species and regional differences, which render compilation of meaningful data difficult. Available evidence indicates that vitamin A has a predominantly proliferative effect on mature rodent and human epidermis, which may be dose-dependent. The ancient concept of an "antikeratinizing effect" is thus incomplete, though possibly not incorrect, when applied to mammalian epidermis. Mucous metaplasia in response to excess vitamin A, though consistently seen in embryonic chicken skin, is not a feature of the mammalian response, except in specific epithelia with "mucoid potential." The precise mode of action at the molecular level remains unknown, but lysosomal labilization may be of major importance.

Author Affiliations
Rochester, Minn

From the Mayo Graduate School of Medicine, Rochester, Minn.

Footnotes
Accepted for publication Jan 4, 1972.

Reprint requests to Section of Publications, Mayo Clinic, Rochester, Minn 55901.

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

A PMLRARA Transgene Results in a Retinoid-deficient Phenotype Associated with Enhanced Susceptibility to Skin Tumorigenesis
Hansen et al.
Cancer Res. 2003;63:5257-5265.
ABSTRACT | FULL TEXT  

Pachyonychia Congenita: Electron Microscopic and Epidermal Glycoprotein Assessment Before and During Isotretinoin Treatment
Thomas et al.
Arch Dermatol 1984;120:1475-1479.
ABSTRACT  

Nature of Skin Fragility in Patients Receiving Retinoids for Systemic Effect
Williams and Elias
Arch Dermatol 1981;117:611-619.
ABSTRACT  

Retinoids, Cancer, and the Skin
Elias and Williams
Arch Dermatol 1981;117:160-180.
ABSTRACT  

Mal de Meleda Treated With 13-cis Retinoic Acid
Reed et al.
Arch Dermatol 1979;115:605-608.
ABSTRACT  

Hypertrophic Scar After Cryotherapy and Topical Tretinoin
Peck
Arch Dermatol 1973;108:819-822.
ABSTRACT  

Topical Vitamin A Acid in the Treatment of Psoriasis
Peck et al.
Arch Dermatol 1973;107:245-248.
ABSTRACT