This Article  • References  • Full text PDF  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Citing articles on HighWire  • Citing articles on Web of Science (26)  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Social Bookmarking   What's this?

S. Madli Puhvel, PhD; Ronald M. Reisner, MD

Arch Dermatol. 1972;106(1):45-49.

Abstract
The effect of various antibiotics on the hydrolytic activity of partially purified lipases from Corynebacterium acnes on tributyrin was studied by continuous potentiometric titration and by agar diffusion assays. Tetracycline hydrochloride, chlortetracycline hydrochloride, and demeclocycline hydrochloride inhibited C acnes lipase activity by 70% to 80% at concentrations of 500 µg/ml of substrate. Penicillin G potassium, erythromycin, neomycin sulfate, and streptomycin sulfate had no inhibitory effect on C acnes lipase activity.

However, the minimum concentration of tetracyclines which produced detectable lipase inhibition in vitro was higher than the concentrations of tetracyclines found in skin during the usual regimen of tetracycline therapy in acne vulgaris, and much higher than the minimum bacteriostatic levels of tetracyclines used on C acnes in vitro.

Author Affiliations
Los Angeles

From the Department of Medicine, Division of Dermatology, UCLA School of Medicine, Los Angeles (Drs. Puhvel and Reisner), and the Department of Medicine, Division of Dermatology, Harbor General Hospital, Torrance, Calif (Dr. Reisner).

Footnotes
Accepted for publication Oct 26, 1971.

Read before the national meeting of the American Society for Microbiology, Minneapolis, May 4, 1971.

Reprint requests to Department of Medicine, Division of Dermatology, UCLA School of Medicine, Los Angeles 90024 (Dr. Puhvel).

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

Synthesis and Antibacterial Evaluation of Novel Water-Soluble Organic Peroxides
Liu et al.
Antimicrob. Agents Chemother. 1998;42:911-915.
ABSTRACT | FULL TEXT  

Systemic Antibiotics for Treatment of Acne Vulgaris: Efficacy and Safety
Arch Dermatol 1975;111:1630-1636.
ABSTRACT  

Acne Vulgaris and Free Fatty Acids: A Review and Criticism
Voss
Arch Dermatol 1974;109:894-898.
ABSTRACT  

Tetracyclines in the Treatment of Acne
Jones
Arch Dermatol 1972;106:923-923.
ABSTRACT