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Gary L. Peck, MD; Stephen B. Guss, MD; Douglas J. Key, MD

Arch Dermatol. 1972;106(2):172-176.

Abstract
Nine of 12 patients treated in a double-blind manner with topical 1.0% lomustine had complete resolution of psoriatic plaques in four to six weeks. Local toxicity included cutaneous irritation with epidermal separation, hyperpigmentation, telangiectasia, and cutaneous pain and pruritus. Two patients developed temporary bone marrow suppression. At present, four of the 12 patients have received 18-month remissions.

Author Affiliations
Bethesda, Md

From the Dermatology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Md.

Footnotes
Accepted for publication March 6, 1972.

Reprint requests to Dermatology Branch, National Cancer Institute, National Institutes of Health, Building 10, Room 12-N-238, Bethesda, Md 20014 (Dr. Peck).

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