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Herschel S. Zackheim, MD

Arch Dermatol. 1972;106(2):177-182.

Abstract
Five patients with mycosis fungoides were treated topically with three nitrosourea compounds, 1-(2-chloroethyl)-1-nitrosourea (NSC 47547), 1-methyl-1-nitrosourea (NSC 23909), and 1,3-bis(2-chloroethyl)-1-nitrosourea (carmustine [NSC 409962, BCNU]), using aqueous and alcoholic solutions of 0.025% to 0.075% (0.25 to 0.75 mg/ml). Clearing of some plaques was achieved with all three compounds, but was most consistently obtained with NSC 47547. Cross sensitivity to mechlorethamine did not occur. This is an early efficacy experimental trial, and more work must be done before it can be recommended for nonexperimental use.

Author Affiliations
San Francisco

From the Department of Dermatology, University of California School of Medicine, San Francisco. Part of this study was done at the Department of Dermatology, Stanford University, Stanford, Calif.

Footnotes
Accepted for publication March 8, 1972.

Reprint requests to Department of Dermatology, University of California School of Medicine, San Francisco 94122 (Dr. Zackheim).

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