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Immunofluorescent Studies

Samuel F. Bean, MD; Margaret Waisman, MD; Beno Michel, MD; Charles I. Thomas, MD; John M. Knox, MD; Mark Levine, MD

Arch Dermatol. 1972;106(2):195-199.

Abstract
Direct immunofluorescent staining of specimens from the conjunctiva, buccal mucosa, and skin of four patients with cicatricial pemphigoid revealed the presence of tissue-fixed, basement membrane zone antibodies similar to the basement membrane zone fluorescent staining characteristic of bullous pemphigoid. No circulating basement membrane zone antibodies could be detected in the sera of these patients. These findings suggest a relationship between cicatricial pemphigoid and bullous pemphigoid and that cicatricial pemphigoid may represent a forme fruste of bullous pemphigoid with predilection for mucous membrane and a tendency to scarring.

Author Affiliations
Houston; Cleveland; Houston; Cleveland

From the Department of Dermatology, Baylor College of Medicine, Houston (Drs. Bean and Knox), and the Division of Dermatology (Drs. Waisman and Michel) and the Department of; Ophthalmology (Drs. Thomas and Levine), Case Western Reserve University School of Medicine, Cleveland.

Footnotes
Accepted for publication Oct 19, 1971.

Reprint requests to Diagnostic Clinic of Houston, 6448 Fannin, Houston 77025 (Dr. Bean).

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