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Prof Hans-Jürgen Bandmann; Prof Charles D. Calnan; Etain Cronin, BM, MRCP; Prof Sigfrid Fregert; Prof Niels Hjorth; Prof Bertil Magnusson; Howard Maibach, MD; Prof Klaus E. Malten; Prof Carlo L. Meneghini; Prof Veikko Pirilä; Darrell S. Wilkinson, BM, FRCP

Arch Dermatol. 1972;106(3):335-337.

Abstract
Four thousand consecutive patients with eczema in five European clinics were tested with a series of medicaments. These included 20% neomycin sulfate, 5% benzocaine, 5% iodochlorhydroxyquin (Vioform), 15% parabens, 30% wool alcohols, and 5% chlorquinaldol (Sterosan), in a petrolatum vehicle.

Of the 4,000, 560 (14%) were judged to have a relevant medicament dermatitis; this represented one third of all allergic contact dermatitis in this series. Forty percent of women with dermatitis of the lower leg had medicament sensitivity. Benzocaine and neomycin elicit positive reactions most frequently, wool alcohols somewhat less, whereas iodochlorhydroxyquin, chlorquinaldol, and parabens give less than 2% positive reactions. In spite of the geographical differences, greater than 80% of applied medicament dermatitis could be diagnosed with the standard patch test series.

Author Affiliations
Munich, Germany; London; London; Lund, Sweden; Hellerup, Denmark; Malmö, Sweden; San Francisco; Nijmegen, Holland; Bari, Italy; Helsinki; Amersham, England

From the Department of Dermatology, University of California School of Medicine, San Francisco. The authors are members of the International Contact Dermatitis Research Group.

Footnotes
Accepted for publication Oct 9, 1971.

Reprint requests to University of California Medical Center, San Francisco 94122 (Dr. Maibach).

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