Electron Microscopic Study of Reticulohistiocytoma: An Unusual Case of Congenital, Self-Healing Reticulohistiocytosis

doi:10.1001/archderm.1973.01620170071020

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Vol. 107 No. 2, February 1973

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Electron Microscopic Study of Reticulohistiocytoma

An Unusual Case of Congenital, Self-Healing Reticulohistiocytosis

Ken Hashimoto, MD; Martin S. Pritzker, MD

Arch Dermatol. 1973;107(2):263-270.

Abstract

One case of congenital, multicentric reticulohistiocytoma ofthe skin was followed up for more than a year. All lesions disappearedwithin 31/2 months, and there was no recurrence. Electron microscopicexamination revealed typical histiocytic proliferation. Characteristically,the majority of the tumor cells contained numerous dense bodies,many of which showed myelin-like laminations. About 10% of thetumor cells contained Langerhans' cell granules. Some of thesecells also contained myelinated dense bodies. These features,which are not commonly seen in Langerhans' cells of histiocytosisX, and the benign course of the disease were emphasized as differentiatingpoints of this entity from histiocytosis X. No cell exhibiteda resemblance to ganglioneuronal cells.

Author Affiliations

Memphis

From Veterans Administration Hospital, and the Division of Dermatology, Department of Medicine, University of Tennessee, Memphis.

Footnotes

Accepted for publication Sept 5, 1972.

Reprint requests to Electron Microscopy Laboratory, VeteransAdministration Hospital, 1030 Jefferson Ave, Memphis 38104 (Dr.Hashimoto).

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