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Clinical and Immunologic Correlation

Henry H. Roenigk, Jr., MD; Sharad Deodhar, PhD, MD

Arch Dermatol. 1973;107(3):353-357.

Abstract
A prospective study of ten patients with early pemphigus, who were treated with azathioprine, is described. The dosage of azathioprine was 50 to 250 mg/day. Nine of the ten patients had good to excellent results. Seven of the ten patients were either never given corticosteroids or had the corticosteroids completely withdrawn. There was good clinical and immunologic correlation in eight of the ten patients. There were no significant side-effects and no wound-healing problems. High-dose corticosteroid therapy is still the treatment of choice for severe, generalized, toxic pemphigus, but in early pemphigus azathioprine alone may control the disease.

Author Affiliations
Cleveland

From the departments of dermatology (Dr. Roenigk) and immunopathology (Dr. Deodhar), Cleveland Clinic Foundation, Cleveland.

Footnotes
Accepted for publication Aug 15, 1972.

Reprint requests to Department of Dermatology, Cleveland Clinic Foundation, 9500 Euclid Ave, Cleveland 44106 (Dr. Roenigk).

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