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Albert M. Kligman, MD, PhD; Francis P. Goldstein

Arch Dermatol. 1973;107(4):548-550.

Abstract
Neither with sunlight nor with intense long ultraviolet LUV radiation was it possible to produce phototoxic reactions with orally administered doses of methoxsalen (8-methoxypsoralen [8-MOP]) customarily used to treat vitiligo and to promote tanning.

The optimal time of exposure was two hours after ingestion. A single dose was as effective as the same dose given daily.

Hot quartz ultraviolet lamps should not be used. A suitable source of LUV light is a bank of four black lights placed close to the skin. With 45 minutes of exposure at 6 inches, 40 mg of methoxsalen will consistently produce a phototoxic response. The dose may be raised to 60 mg as required.

Author Affiliations
Philadelphia

From the Department of Dermatology, University of Pennsylvania School of Medicine, Philadelphia.

Footnotes
Accepted for publication Dec 18, 1972.

Reprint requests to Department of Dermatology, Duhring Laboratories, Hospital of the University of Pennsylvania, Philadelphia 19104 (Dr. Kligman).

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