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Klaus Konrad, MD; Klaus Wolff, MD

Arch Dermatol. 1973;107(6):853-860.

Abstract
This study was performed to determine if, in whites, different states of hyperpigmentation exhibit different distribution patterns of melanosomes; if melanosome size influences the distribution of melanosomes; and if melanosome distribution correlates with the degree of pigmentation. It was found by electron microscopic investigations that (1) the distribution patterns of melanosomes vary in different hyperpigmentary states; (2) there is a striking tendency for small melanosomes to be complexed and for large ones to be dispersed as singles; and (3) in whites, there is no definite relationship between the degree of pigmentation and the distribution pattern of melanosomes. Hence, the size of melanosomes determines the distribution pattern but the distribution pattern alone does not correlate with the intensity of pigmentation.

Author Affiliations
Vienna

From the Department of Dermatology I, University of Vienna.

Footnotes
Accepted for publication Nov 27, 1972.

Read in part at the joint meeting of the Society for Investigative Dermatology Inc, and the European Society for Dermatological Research, Amsterdam, May 18, 1972.

Reprint requests to Department of Dermatology I, University of Vienna, 1090 Vienna, Alserstrasse 4, Austria (Dr. Konrad).

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