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Analysis of 40 New Cases

Martin H. Brownstein, MD; Lewis Shapiro, MD

Arch Dermatol. 1973;107(6):866-869.

Abstract
Clinical and histopathologic features of 40 new examples of trichilemmoma were analyzed. Lesions were almost invariably solitary, asymptomatic, and located on the face. Two-thirds of the patients were men; median age was 59 years; median duration was a few months; and clinical impression was frequently basal cell carcinoma or verruca.

Histopathologic examination frequently disclosed lobular acanthosis of glycogenrich clear cells oriented about a follicle. At the edge of the lesion, a palisade of columnar cells, that resembled the outer root sheath of a hair follicle, rested on a wellformed basement membrane.

Trichilemmoma must be differentiated from other clear cell tumors of skin, including Degos acanthoma, clear cell hidradenoma, basal cell carcinoma, sebaceous neoplasms, other follicular tumors such as inverted follicular keratosis and tumor of follicular infundibulum, and metastatic renal carcinoma.

Author Affiliations
New York

From the departments of dermatology and pathology, New York Medical College-Metropolitan Hospital Center (Dr. Brownstein), and the departments of dermatology and pathology, College of Physicians and Surgeons, Columbia University, the dermatology and pathology services, Presbyterian Hospital (Dr. Shapiro), and the Laboratory of Dermatopathology, Great Neck, NY (Drs. Brownstein and Shapiro).

Footnotes
Accepted for publication Jan 11, 1973.

Read in part before the annual meeting of the American Society of Dermatopathology, Bal Harbour, Fla, Dec 1, 1972.

Reprint requests to Laboratory of Dermatopathology, PO Box 571, Great Neck, NY 11022 (Dr. Brownstein).

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