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HL-A Antigens in Pemphigus
Stephen I. Katz, MD;
Mark V. Dahl, MD;
Neal Penneys, MD;
Robert J. Trapani, MD;
Nicholas Rogentine, MD
Arch Dermatol. 1973;108(1):53-55.
Abstract
We studied the frequency of 20 human leukocyte (HL-A) alloantigens in 18 patients with pemphigus. HL-A13 was significantly increased as compared to a normal racial control group. Five of the 18 patients (28%) had HL-A13, whereas only 10 of 251 controls (4%) had the same antigen. Sera from patients did not react with their own lymphocytes nor did they have any anti-HL-A antibodies in lymphocytotoxicity tests. Anti HL-A sera did not react with the pemphigus interepithelial antigen in an indirect immunofluorescent test.
Author Affiliations
Washington, DC; Miami, Fla; Bethesda, Md
From the Dermatology Service, Walter Reed General Hospital, Washington, DC (Drs. Katz and Dahl); the Department of Dermatology, University of Miami and Veterans Administration Hospital, Miami, Fla (Dr. Penneys); Microbiological Associates, Inc. (Dr. Trapani) and the Immunology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Md (Dr. Rogentine).
Footnotes
Accepted for publication March 1, 1973.
Reprint requests to Dermatology Department, University of California-San Francisco Medical Center, San Francisco (Dr. Dahl).
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