 |
|
Topical Steroid-Antibiotic CombinationsAssay of Use in Experimentally Induced Human Infections
Richard R. Marples, BM, MSc, MRCPath;
Alfredo Rebora, MD;
Albert M. Kligman, MD, PhD
Arch Dermatol. 1973;108(2):237-240.
Abstract
Whether antibiotics should be combined with topical steroids in the treatment of chronic dermatoses is a question that is extraordinarily difficult to answer. The alternative proposed in this study is appraisal of efficacy in experimental human infection with Staphylococcus aureus and Candida albicans. With a broad spectrum steroid-antibiotic combination containing triamcinolone acetonide, neomycin gramicidin, and nystatin, it was possible to show that omission of any one component decreased the effectiveness of the mixture. The steroid by itself suppressed the experimental lesion without influencing the multiplication of the pathogen.
Author Affiliations
Philadelphia
From the Department of Dermatology, University of Pennsylvania School of Medicine, Philadelphia. Dr. Marples is now at the Central Public Health Laboratory, Colindale Ave, London. Dr. Rebora is now at the Clinica Dermatologica Universita, Genoa, Italy.
Footnotes
Accepted for publication April 4, 1973.
Reprint requests to Department of Dermatology, Duhring Laboratories, Hospital of the University of Pennsylvania, Philadelphia 19104 (Dr. Kligman).
 CiteULike  Connotea  Del.icio.us  Digg  Facebook  Reddit  Technorati  Twitter
What's this?
THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES
Cytokine expression induced by Candida albicans in a model of cutaneous candidosis based on reconstituted human epidermis
SCHALLER et al.
J Med Microbiol 2002;51:672-676.
ABSTRACT
| FULL TEXT
Albert Kligman--Master of Dermatology
Leyden
Arch Dermatol 1991;127:1392-1393.
ABSTRACT
|
