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Lawrence S. Krain, MD; Paul I. Terasaki, PhD; Victor D. Newcomer, MD; Max R. Mickey, PhD

Arch Dermatol. 1973;108(6):803-805.

Abstract
In order to determine if there was an association of pemphigus vulgaris and any antigenic specificity of the HL-A system, 43 unrelated white patients with pemphigus vulgaris were typed for HL-A by the microdroplet lymphocyte cytotoxicity test. HL-A10 was present in 17 of 28 unrelated Jewish patients with pemphigus vulgaris (60.7%) as compared to 19 of 94 Jewish control patients (20.2%) (P<.0001). Among female patients, the occurrence of HL-A10 was 71% and among male patients, 45%. HL-A10 was elevated but not significantly associated with pemphigus vulgaris in non-Jewish whites. No significant associations were noted for other HL-A specificities. A pemphigus susceptibility gene linked to HL-A is postulated.

Author Affiliations
Los Angeles

From the departments of medicine (Division of Dermatology), biomathematics, and surgery, University of California, Los Angeles School of Medicine, Los Angeles. Dr. Krain is now Executive Coordinator, National Clinical Cooperative Melanoma Project, Harvard Medical School, Massachusetts General Hospital, Boston.

Footnotes
Accepted for publication Aug 14, 1973.

Read before the Section on Dermatology at the 122nd annual convention of the American Medical Association, New York, June 26, 1973.

Reprint requests to Department of Surgery, University of California, School of Medicine, Los Angeles 90024 (Dr. Terasaki).

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