IgE Levels in Atopic Dermatitis

doi:10.1001/archderm.1973.01620270032008

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Vol. 108 No. 6, December 1973

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IgE Levels in Atopic Dermatitis

Stephen P. Stone, MD; Sigfrid A. Muller, MD; Gerald J. Gleich, MD

Arch Dermatol. 1973;108(6):806-811.

Abstract

Fifty-eight patients with a clinical diagnosis of atopic dermatitiswere evaluated. Serum IgE levels, measured by a double antibodyradioimmunossay, varied from 2 to 46,560 ng/ml in 55 patients(mean, 6,793 ng/ml median, 2,639 ng/ml). The three other patientshad extremely high IgE values (77,704, 101,663, and 156,444ng/ml). Three patients with atopic dermatitis had subnormalserum IgE levels and may represent a distinctive subgroup thatshould be studied further. Statistical analysis by nonparametricmethods showed significant correlation of the serum IgE levelwith the extent of skin involvement. The ``atopic index," definedas the ratio of the number of positive intradermal skin teststo the number administered, and the intensity of the delayedblanch phenomenon also correlated significantly with IgE level.There was no correlation between IgE level and the subjectiveassessment of severity of dermatitis.

Author Affiliations

Rochester, Minn

From the Mayo Clinic and Mayo Foundation, Rochester Minn.

Footnotes

Accepted for publication July 5, 1973.

Read before the Section on Dermatology at the 122nd annual conventionof the American Medical Association, New York, June 26, 1973.

Reprint requests to Section of Publication, Mayo Clinic, 200First St SW, Rochester, MN 55901 (Dr. Stone).

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