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Stephen P. Stone, MD; Sigfrid A. Muller, MD; Gerald J. Gleich, MD

Arch Dermatol. 1973;108(6):806-811.

Abstract
Fifty-eight patients with a clinical diagnosis of atopic dermatitis were evaluated. Serum IgE levels, measured by a double antibody radioimmunossay, varied from 2 to 46,560 ng/ml in 55 patients (mean, 6,793 ng/ml median, 2,639 ng/ml). The three other patients had extremely high IgE values (77,704, 101,663, and 156,444 ng/ml). Three patients with atopic dermatitis had subnormal serum IgE levels and may represent a distinctive subgroup that should be studied further. Statistical analysis by nonparametric methods showed significant correlation of the serum IgE level with the extent of skin involvement. The ``atopic index," defined as the ratio of the number of positive intradermal skin tests to the number administered, and the intensity of the delayed blanch phenomenon also correlated significantly with IgE level. There was no correlation between IgE level and the subjective assessment of severity of dermatitis.

Author Affiliations
Rochester, Minn

From the Mayo Clinic and Mayo Foundation, Rochester Minn.

Footnotes
Accepted for publication July 5, 1973.

Read before the Section on Dermatology at the 122nd annual convention of the American Medical Association, New York, June 26, 1973.

Reprint requests to Section of Publication, Mayo Clinic, 200 First St SW, Rochester, MN 55901 (Dr. Stone).

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