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Purpura Caused by Food and Drug Additives
Dr. Ged Michaëlsson;
Dr. Lars Pettersson;
Lennart Juhlin, MD
Arch Dermatol. 1974;109(1):49-52.
Abstract
Seven patients with allergic vascular purpura displayed hypersensitivity reactions after ingestion of azo dyes and benzoic acid compounds. All reacted with purpura after oral provocation with azo dyes. Three patients also developed purpura after ingesting benzoic acid compounds and four developed purpura after taking aspirin. Mild purpuric reactions after provocation are more easily revealed if the skin is pretreated with a nicotinic acid ester. The patients improved on a diet free from the additives. Beneficial effects, with decreased purpuric reactions after provocation, have also been observed from treatment with phenformin and ethylestrenol.
Author Affiliations
Uppsala, Sweden
From the Department of Dermatology, University Hospital, Uppsala University, Uppsala, Sweden.
Footnotes
Accepted for publication June 14, 1973.
Reprint requests to Department of Dermatology, University Hospital, Uppsala University, Uppsala 750 14, Sweden (Dr. Michaëlsson).
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