This Article  • References  • Full text PDF  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Citing articles on HighWire  • Citing articles on Web of Science (109)  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Social Bookmarking   What's this?

Eugene M. Farber, MD; M. Lexie Nall, MA; William Watson, MD

Arch Dermatol. 1974;109(2):207-211.

Abstract
The history of psoriasis in 95 twin individuals was compared with that of a matched control group of singleton (nontwin) psoriatics. The findings indicate that twin members with psoriasis do not differ from psoriatic singletons in the general population, with respect to clinical manifestations of the disease.

Psoriasis in concordant monozygotic twin pairs tended to be similar, with respect to age of onset, distribution pattern, severity, and course. This pattern was not found in concordant dizygotic twin pairs.

The striking difference in rate of concordance for psoriasis between monozygotic and dizygotic twin pairs indicates that there is a heritable contribution to the etiology of psoriasis. The fact that not all monozygotic twin pairs are concordant suggests that environmental factors are also important and supports a theory of a multifactorial mode of inheritance for psoriasis.

Author Affiliations
Stanford, Calif

From the Department of Dermatology, School of Medicine, Stanford University, Stanford, Calif.

Footnotes
Accepted for publication Sept 11, 1973.

Reprint requests to Department of Dermatology, School of Medicine, Stanford University, Stanford, CA 94305 (Dr. Farber).

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

On the heritability of psoriatic arthritis. Disease concordance among monozygotic and dizygotic twins
Pedersen et al.
Ann Rheum Dis 2008;67:1417-1421.
ABSTRACT | FULL TEXT  

Recurrence risk for psoriasis and psoriatic arthritis within sibships
Myers et al.
Rheumatology (Oxford) 2005;44:773-776.
ABSTRACT | FULL TEXT  

Psoriasis
Schön and Boehncke
NEJM 2005;352:1899-1912.
FULL TEXT  

The Genetics of Psoriasis 2001: The Odyssey Continues
Elder et al.
Arch Dermatol 2001;137:1447-1454.
ABSTRACT | FULL TEXT  

The Pathophysiology of Angiogenesis
Polverini
CROBM 1995;6:230-247.
ABSTRACT | FULL TEXT  

The Genetics of Psoriasis
Elder et al.
Arch Dermatol 1994;130:216-224.
ABSTRACT  

Cyclosporine in Psoriasis Treatment: Inhibition of Keratinocyte Cell-Cycle Progression in G1 Independent of Effects on Transforming Growth Factor {alpha}/Epidermal Growth Factor Receptor Pathways
Khandke et al.
Arch Dermatol 1991;127:1172-1179.
ABSTRACT  

The Cytokine Network in Psoriasis
Nickoloff
Arch Dermatol 1991;127:871-884.
ABSTRACT  

Human Leukocyte Antigen Haplotype Sharing in Siblings With Psoriasis-Reply
Suarez-Almazor and Russell
Arch Dermatol 1991;127:585-586.
ABSTRACT  

The Genetics of Psoriasis: Haplotype Sharing in Siblings With the Disease
Suarez-Almazor and Russell
Arch Dermatol 1990;126:1040-1042.
ABSTRACT  

HLA Region Genes and Immune Activation in the Pathogenesis of Psoriasis
Gottlieb and Krueger
Arch Dermatol 1990;126:1083-1086.
ABSTRACT  

`Twin' Psoriasis in Monozygotic Twins
Pisani and Ruocco
Arch Dermatol 1984;120:1418-1419.
ABSTRACT  

Psoriasis in an Unselected Series of Twins
Brandrup et al.
Arch Dermatol 1978;114:874-878.
ABSTRACT  

Skin Diseases in Twins
Lynfield
Arch Dermatol 1974;110:722-724.
ABSTRACT