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David L. Cram, MD; Michael R. Griffith, DDS; Kimie Fukuyama, MD

Arch Dermatol. 1974;109(2):235-238.

Abstract
Two patients with cicatricial pemphigoid had antibodies in their sera directed to the intercellular area of epithelium. Their disease began with mucosal ulcerations and conjunctival lesions, which resulted in scarring. Direct immunofluorescence revealed bound IgG at the basement membrane zone of involved tissue of the eyes and mouth, but ultraviolet light testing failed to produce new lesions in normal-appearing skin. The finding of circulating intercellular antibodies in cicatricial pemphigold could add confusion to its diagnosis. The relationship of this finding to pemphigus, bullous pemphigoid and to skin conditions producing pemphigus-like antibodies is considered.

Author Affiliations
San Francisco

From the Department of Dermatology, University of California School of Medicine, San Francisco.

Footnotes
Accepted for publication Sept 28, 1973.

Reprint requests to Department of Dermatology, University of California School of Medicine, San Francisco 94143 (Dr. Cram).

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